Staphylococcus aureus proteins (S. aureus proteins)

Staphylococcus aureus proteins represent the complete set of proteins expressed by the Gram-positive bacterium Staphylococcus aureus, a major human pathogen. This proteome includes essential enzymes for cell wall biosynthesis, such as penicillin-binding proteins (PBPs), as well as machinery for protein synthesis and DNA replication [1][2]. Additionally, S. aureus produces numerous virulence factors, including toxins (e.g., alpha-hemolysin) and enzymes (e.g., coagulase) that facilitate tissue invasion and immune evasion [3]. These proteins serve as the primary targets for a broad range of antibiotics, including beta-lactams, glycopeptides, and oxazolidinones [4]. However, the high adaptability of the S. aureus proteome has led to the emergence of resistant strains, most notably Methicillin-resistant S. aureus (MRSA), which poses a severe threat to global public health [5]. Understanding the functional diversity of these proteins is crucial for the development of new antimicrobial strategies and vaccines [6][7].

Other names

Staphylococcus aureus proteomeStaphylococcal proteinsStaphylococcus aureus antigens

Drugs targeting these proteins act through various mechanisms including the inhibition of peptidoglycan cross-linking (beta-lactams), inhibition of protein synthesis by binding to ribosomal subunits (macrolides, aminoglycosides), and inhibition of DNA topoisomerases (fluoroquinolones).