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Target intelligence / Profile preview
Staphylococcus aureus Type 5 Capsular Polysaccharide (CP5)
- Target
- CP5
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Glycan
01
Overview
The type 5 capsular polysaccharide (CP5) is a surface-associated carbohydrate structure produced by Staphylococcus aureus. It is one of the two predominant capsular serotypes (the other being type 8, CP8) found among clinical isolates of S. aureus. The capsule forms a protective layer around the bacterial cell wall. CP5 plays a critical role in S. aureus virulence by impeding phagocytosis, which allows the bacteria to persist in the bloodstream and evade immune clearance. Purified CP5 has been investigated as a vaccine target antigen for preventing staphylococcal infections.
02
Mechanism of action
Blocking interaction with immune cells, preventing phagocytosis
03
Biological functions
Immune evasionInhibition of phagocytosisMasking of surface proteins
04
Disease associations
InfectionStaphylococcus aureus infectionAbscess formation
05
Safety considerations
Potential for serotype replacement if vaccine only targets CP5Need for broad protection against multiple S. aureus strains
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