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Target intelligence / Profile preview
Staphylococcus aureus Type 8 Capsular Polysaccharide (CP8)
- Target
- CP8
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Carbohydrate
01
Overview
The type 8 capsular polysaccharide (CP8) is a surface-associated carbohydrate polymer produced by Staphylococcus aureus. It is a major virulence factor, impeding phagocytosis and promoting immune evasion. CP8 is one of the most prevalent capsule types found in clinical isolates, making it a key target for vaccine development. The repeating unit is a trisaccharide composed of N-acetyl-d-mannosaminuronic acid, N-acetyl-l-fucosamine, and N-acetyl-d-fucosamine. Antibodies against CP8 have shown protective effects in animal models.
- Other names
- S. aureus CP8Type 8 Capsular PolysaccharideCP8 polysaccharide
02
Mechanism of action
Antibodies targeting CP8 promote opsonophagocytosis and complement-mediated killing of S. aureus.
03
Biological functions
Immune evasionInhibition of phagocytosisModulation of complement depositionPromotion of abscess formationAdherence/Colonization
04
Disease associations
InfectionStaphylococcus aureus infectionBacteremia
05
Safety considerations
Potential for serotype replacement in vaccine developmentNeed for broad-spectrum coverage against multiple S. aureus strains
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