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Target intelligence / Profile preview
Staphylococcus capitis E12 (S. capitis E12)
- Target
- S. capitis E12
- Molecular classification
- Bacterium, Probiotic
01
Overview
Staphylococcus capitis E12 is a strain of coagulase-negative, Gram-positive bacteria isolated from healthy human skin. It exhibits potent antimicrobial activity against Cutibacterium acnes (C. acnes), the bacterium implicated in acne vulgaris. This strain produces four distinct phenol-soluble modulins (PSMs) that act synergistically to inhibit C. acnes growth. It is being explored as a biotherapeutic approach for treating acne vulgaris.
- Other names
- S.capititsE12
02
Mechanism of action
Secretion of phenol-soluble modulins (PSMs) that selectively kill Cutibacterium acnes.
03
Biological functions
Antimicrobial activityMicrobial competitionSkin microbiome modulation
04
Disease associations
Acne vulgaris treatmentSkin health
05
Safety considerations
Potential for opportunistic infection (though not reported for strain E12 specifically)Risk of transferring antibiotic resistance genes (though not reported for strain E12 specifically)
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