Staphylococcus epidermidis cell-surface receptor

Staphylococcus epidermidis cell-surface receptors comprise a diverse group of proteins and polysaccharides anchored to the bacterial cell wall that mediate interactions with the host environment and other bacteria. The most prominent members are the Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMMs), such as the fibrinogen-binding protein SdrG (Fbe), the autolysin/adhesin AtlE, and the accumulation-associated protein (Aap). These molecules are critical for the initial attachment of the bacteria to medical devices and host tissues, as well as the subsequent formation of robust biofilms, which protect the pathogen from the host immune system and antibiotics. Additionally, the AgrC receptor serves as a key component of the quorum-sensing system, regulating virulence factor expression in response to population density. While no drugs targeting these specific receptors are currently FDA-approved, they are significant targets for the development of novel anti-infective strategies, including monoclonal antibodies and small-molecule inhibitors designed to prevent biofilm-associated infections and sepsis.

Other names

MSCRAMMsMicrobial surface components recognizing adhesive matrix moleculesAdhesinsCell wall-anchored proteinsSerine-aspartate repeat protein G (SdrG)Fibrinogen-binding protein (Fbe)Accumulation-associated protein (Aap)Autolysin/adhesin AtlEAgrC receptor

Inhibition of bacterial adhesion to host tissues or medical devices, disruption of biofilm formation, or interference with quorum-sensing signaling.