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Target intelligence / Profile preview
Staphylococcus leukocidin ED (LukED)
- Target
- LukED
- Molecular classification
- Pore-forming toxin, Bicomponent toxin, Cytotoxin
01
Overview
Staphylococcus leukocidin ED (LukED) is a bicomponent, pore-forming cytotoxin produced by Staphylococcus aureus. It targets and lyses host immune cells, particularly neutrophils and erythrocytes, by binding to chemokine receptors such as ACKR1, CCR2, and CCR5 and forming a transmembrane pore. This promotes bacterial survival and virulence, making it a major virulence factor in systemic S. aureus infections. Expression levels can be modulated by antibiotic exposure.
02
Mechanism of action
Forms oligomeric β-barrel pores in cell membranes, leading to cell lysis and necrosis.
03
Biological functions
Immune evasionCell lysisNutrient acquisitionPore formation
04
Disease associations
InfectionBacterial virulenceBloodstream infectionOcular infections
05
Safety considerations
Potential for off-target effects due to chemokine receptor homologyDevelopment of resistanceToxin-mediated tissue damage
06
Interacting drugs
Antibiotics (variable effects on expression)
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