Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Staphylococcus LukGH (LukGH)
- Target
- LukGH
- Molecular classification
- Pore-forming toxin, Bi-component toxin, Leukocidin
01
Overview
Staphylococcus LukGH (also known as leukocidin GH or LukAB) is a potent bi-component pore-forming cytotoxin produced by *Staphylococcus aureus*. It targets and lyses human phagocytic cells, such as neutrophils and macrophages, by forming a pore complex in the cell membrane after binding to CD11b, contributing significantly to immune evasion during infection. Unlike other bi-component leukocidins, LukGH forms a heterodimer in solution before receptor binding.
- Other names
- Leukocidin GHLukABLeukotoxin GHLeukocidin AB
02
Mechanism of action
Forms a heterodimer (LukG and LukH) that binds to CD11b on phagocytes, leading to oligomerization into a pore complex in the cell membrane and subsequent cell lysis.
03
Biological functions
Cell lysisImmune evasionNeutrophil extracellular trap (NET) inductionPhagocyte inactivation
04
Disease associations
InfectionStaphylococcus aureus infectionInflammation
05
Safety considerations
Lysis of immune cells (neutrophils, macrophages)Potential for off-target effects on other CD11b-expressing cells
Beyond the preview
Go deeper on Staphylococcus LukGH (LukGH).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Staphylococcus LukGH (LukGH).