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Target intelligence / Profile preview
Staphylococcus saprophyticus (S. saprophyticus)
- Target
- S. saprophyticus
- Molecular classification
- Other
01
Overview
Staphylococcus saprophyticus is a gram-positive, coagulase-negative, nonmotile coccus (0.8-1.2 µm diameter) that commonly causes community-acquired urinary tract infections (UTIs), particularly in young sexually active women. It colonizes the inguinal/perineal skin, adheres to uroepithelial cells via surface proteins, hemagglutinins, lipase, and biofilms, produces urease to promote growth and stone formation, and shows novobiocin resistance distinguishing it from similar staphylococci like S. epidermidis. Virulence involves biofilm production (protein-eDNA-polysaccharide matrix in most strains), lower adhesion proteins than other staphylococci, and heavy metal resistance; infections are treated with antibiotics like nitrofurantoin but can progress to pyelonephritis if untreated.
- Other names
- Staphylococcus saprophyticus subsp. saprophyticusS. s. saprophyticus
02
Mechanism of action
Urease inhibition delays growth in artificial urine
03
Biological functions
Lipid metabolism on skinPrimary barrier against pathogensAdherence to urogenital cellsBiofilm formationUrease activity for growth in urine
04
Disease associations
Infection
05
Safety considerations
Biofilm formation increases antibiotic resistance (e.g., 32-fold to multiple drugs)Resistance to novobiocinHeavy metal resistance (copper, cadmium, arsenic)Potential for bacteremia and pyelonephritis if untreated
06
Interacting drugs
Nitrofurantoin
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