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StAR-related lipid transfer domain containing 8 (STARD8)

Target: STARD8
Molecular classification: Rho GTPase activating protein (RhoGAP), START domain-containing protein (StAR-related lipid transfer domain)

Overview

StAR-related lipid transfer domain containing 8 (STARD8) is a member of the Rho GTPase activating proteins family, with a characteristic lipid-binding START domain. It regulates GTPase activity (especially RHOA and CDC42), localizes to focal adhesions, regulates cell morphology, orchestrates membrane trafficking, and maintains organelle integrity. STARD8’s tumor suppressor function is indicated by inactivation mutations in multiple cancers. It plays developmental roles that are conserved across species, serving as a critical regulator of cellular architecture and signaling pathways implicated in cancer pathogenesis.

Other names: DLC3ARHGAP38START-GAP3KIAA0189Deleted in liver cancer 3 proteinSTARTGAP3StAR-related lipid transfer protein 8

Biological functions

Regulation of cell morphology (localizes to focal adhesions, affecting cell shape and structure)Tumor suppression (acts as a tumor suppressor in several cancer types)Regulation of Rho GTPase activity (GTPase activator activity)Lipid binding/transfer (contains a lipid-binding START domain)Orchestration of membrane trafficking and organelle integrityMaintenance of adherens junction integrityDevelopmental function (conserved in Drosophila for testis integrity and gonad development)

Disease associations

Cancer (frameshift mutations in colon cancers, altered expression in gastric cancers, "deleted in liver cancer")Associated disorders noted: Craniofrontonasal syndrome, Baraitser-Winter syndrome 1

Biomarkers

Potential: Altered expression/mutation status can act as a biomarker in certain cancers (colon, gastric, liver)

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