Starch-binding domain-containing protein 1 (STBD1)

Starch-binding domain-containing protein 1 (STBD1) is a membrane-associated protein that contains a C-terminal carbohydrate-binding module (CBM20) and an N-terminal hydrophobic region, the latter likely targeting it to the endoplasmic reticulum and/or lysosomal membranes[1][2][3]. STBD1 is predominantly expressed in liver, muscle, and heart, which are key tissues for glycogen storage[3]. Its main biological function is as a cargo receptor mediating glycophagy, the selective autophagic degradation of glycogen, by binding glycogen and interacting with autophagy machinery such as members of the ATG8 protein family (e.g., GABARAPL1)[2][4]. STBD1 binds glycogen through its CBM20 domain and anchors it to intracellular membranes, facilitating its delivery to lysosomes. It may be especially important in the disposal of abnormally structured glycogen, implicating it in the pathogenesis or prevention of several glycogen storage diseases[4]. Current evidence does not support a role for STBD1 as a direct therapeutic target, and there are no drugs or established biomarkers associated with this protein.

Other names

Starch-binding domain-containing protein 1STBD1GENX-3414FLJ41801Genethonin-1Glycophagy cargo receptor STBD1GENEX3414