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Stathmin-1
- Molecular classification
- Microtubule regulator, Oncoprotein
01
Overview
Stathmin-1 is a key regulatory protein involved in microtubule dynamics and cell cycle progression. It destabilizes microtubules by binding to tubulin dimers, preventing their polymerization and promoting disassembly. Overexpression of Stathmin-1 is associated with various cancers due to its role in promoting cell proliferation and survival, making it a potential biomarker and therapeutic target.
- Other names
- MetablastinOncoprotein 18
02
Mechanism of action
Binds tubulin dimers, preventing assembly and promoting disassembly of microtubules
03
Biological functions
Regulation of microtubule dynamicsCell cycle regulationCytoplasmic organizationCell divisionCell motilityRegulation of microtubule filament systems
04
Disease associations
Cancer
05
Safety considerations
Disruption of microtubule dynamics can lead to off-target effectsInhibition may affect normal cell division
06
Biomarkers
STMN1 expression levels for cancer diagnosis/prognosis
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