Stathmin-like 2 pseudogene

Stathmin-like 2 pseudogene (ENSG00000205625) is a non-functional genomic DNA sequence related to the functional stathmin-like 2 (STMN2) gene, sharing sequence similarity but lacking the capacity to encode a protein due to disabling mutations or truncations[7][3]. Pseudogenes such as this arise via duplication or retrotransposition mechanisms and typically have no direct biological or therapeutic utility, though in rare cases, some pseudogenes are transcribed and may have regulatory roles; there is no evidence that ENSG00000205625 has such activity[3][7]. The canonical protein-coding gene for stathmin-like 2 is ENSG00000104435 (STMN2), not this pseudogene[2][7]. Pseudogenes are generally not considered druggable targets and rarely have direct disease roles unless proven to acquire a regulatory function[3][5]. The parent gene, STMN2, plays roles in microtubule dynamics, neuronal growth, and is associated with neurodegenerative conditions, but this functional significance does not apply to the pseudogene[4][6][7].

Other names

Stathmin 2 pseudogeneSTMN2 pseudogene