Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ste20-related Proline Alanine Rich Kinase (SPAK)
- Target
- SPAK
- Molecular classification
- Enzyme, Protein kinase, Serine/threonine kinase, STE Ser/Thr protein kinase family, STE20 subfamily
01
Overview
Ste20-related Proline Alanine Rich Kinase (SPAK) is a serine/threonine kinase that regulates ion transport and cell volume by phosphorylating SLC12A family cation-chloride cotransporters. It is activated by WNK kinases and plays a crucial role in blood pressure regulation and cell volume homeostasis. Dysregulation of SPAK is implicated in hypertension and stroke outcomes. It has emerged as a potential drug target for hypertension and stroke.
- Other names
- STK39STE20/SPS1-related proline-alanine-rich protein kinaseDCHT
02
Mechanism of action
Inhibition of SPAK kinase activity to modulate ion transport, particularly sodium and chloride cotransport
03
Biological functions
Regulation of ion transportRegulation of cell volumePhosphorylation of ion transporters and channelsBlood pressure regulationRegulation of cation-chloride cotransporters
04
Disease associations
HypertensionGordon’s syndrome (pseudohypoaldosteronism type II)Stroke
Beyond the preview
Go deeper on Ste20-related Proline Alanine Rich Kinase (SPAK).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ste20-related Proline Alanine Rich Kinase (SPAK).