STEAP family member 1B (STEAP1B)

STEAP family member 1B (STEAP1B) is a member of the STEAP (six-transmembrane epithelial antigen of the prostate) protein family and is predicted to function as a multi-pass transmembrane protein mainly located at the plasma membrane and endosomes[3][5]. It is highly homologous to STEAP1 but features four predicted transmembrane domains (instead of six for STEAP1). Unlike several STEAP family members that have oxidoreductase enzymatic activity, STEAP1B may not possess NAD(P)H oxidoreductase activity, but its heme group may still be involved in metal ion metabolism, specifically the reduction and uptake of iron and copper[5]. Studies indicate that STEAP1B, and particularly its STEAP1B2 isoform, is overexpressed in cancer cells, especially in prostate cancer, suggesting a possible role in cancer progression, and making it a candidate biomarker or therapeutic target for neoplastic diseases[1][3][4]. STEAP1B is subject to complex post-transcriptional and post-translational regulation. Key points: - STEAP1B is not a classical receptor, enzyme, or transporter; it is best described as a multi-pass transmembrane protein involved in metal ion homeostasis, with specific roles not fully elucidated. - It is overexpressed in some cancers (especially prostate) and may represent a target for cancer biomarker or therapeutic development, but currently no drugs or clinical targeting mechanisms are reported. - Its main function, based on family homology, relates to iron/copper metabolism and possible involvement in cell proliferation and tumorigenesis in cancer cells[1][3][4][5].

Other names

STEAP1BLOC401312STEAP family protein MGC87042