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Target intelligence / Profile preview
Stem Cell Factor (SCF)
- Target
- SCF
- Molecular classification
- Cytokine, Hematopoietic growth factor
01
Overview
Stem Cell Factor (SCF), also known as kit ligand, is a cytokine and hematopoietic growth factor that plays a critical role in the regulation of several biological processes including hematopoiesis (blood cell formation), melanogenesis (pigment cell development), and gametogenesis (germ cell development). It exerts its effects by binding to the c-KIT receptor (CD117), a type III receptor tyrosine kinase.
- Other names
- KIT-ligandKLSteel factorMast cell growth factor
02
Mechanism of action
Binding to c-KIT receptor (CD117) and activation of its intrinsic tyrosine kinase activity.
03
Biological functions
HematopoiesisMelanogenesisGametogenesisCell survivalCell proliferationCell differentiationCell adhesionCell migration
04
Disease associations
Pigmentation defects (e.g., piebaldism)InfertilityAnemiaDefective immune responsesBlood disorders
05
Interacting drugs
G-CSF
06
Biomarkers
CD34+
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