Target intelligence / Profile preview

Stem Cell Factor (SCF)

Target
SCF
Molecular classification
Cytokine, Hematopoietic growth factor
01

Overview

Stem Cell Factor (SCF), also known as kit ligand, is a cytokine and hematopoietic growth factor that plays a critical role in the regulation of several biological processes including hematopoiesis (blood cell formation), melanogenesis (pigment cell development), and gametogenesis (germ cell development). It exerts its effects by binding to the c-KIT receptor (CD117), a type III receptor tyrosine kinase.

Other names
KIT-ligandKLSteel factorMast cell growth factor
02

Mechanism of action

Binding to c-KIT receptor (CD117) and activation of its intrinsic tyrosine kinase activity.

03

Biological functions

HematopoiesisMelanogenesisGametogenesisCell survivalCell proliferationCell differentiationCell adhesionCell migration
04

Disease associations

Pigmentation defects (e.g., piebaldism)InfertilityAnemiaDefective immune responsesBlood disorders
05

Interacting drugs

G-CSF
06

Biomarkers

CD34+

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