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Stem Cell Factor 248 Isoform
- Molecular classification
- Cytokine, Growth factor, Secreted protein
01
Overview
Stem Cell Factor 248 (SCF248) is a 248 amino acid isoform of Stem Cell Factor (KITLG). It contains an additional segment encoded by Exon 6, making it susceptible to enzymatic cleavage and release into the extracellular environment. It is the predominant soluble form of SCF. SCF248 is upregulated during chronic inflammation and fibrosis, and promotes activation/recruitment of mast cells, eosinophils and ILC2s. It signals through the c-Kit receptor and is considered a therapeutic target for fibrotic diseases.
- Other names
- SCF248KITLG isoform 248Cleavable Stem Cell FactorSoluble Stem Cell Factor
02
Mechanism of action
Antibody binding leads to internalization and degradation of surface-expressed SCF248 on fibroblasts/myofibroblasts, reducing activation signals for inflammatory immune cells via c-kit receptor engagement.
03
Biological functions
c-Kit receptor signalingMast cell activationEosinophil activationILC2 activationImmune responseFibrosis promotionInflammationCell proliferationHematopoiesis
04
Disease associations
Idiopathic Pulmonary Fibrosis (IPF)Pulmonary fibrosisChronic AsthmaFood AllergyAnaphylaxisTissue RemodelingInflammation
05
Safety considerations
Potential for off-target effects on SCF220-mediated homeostasis (e.g., erythropoiesis) if the therapeutic targeting is not specific enough.Potential for immune-related adverse events with antibody-based therapies.
06
Interacting drugs
Monoclonal antibodies against SCF248
07
Biomarkers
SCF248 protein levels in lung tissueSCF248 protein levels in serum
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