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Target intelligence / Profile preview
Stem Cell Factor Receptor c-Kit (c-Kit)
- Target
- c-Kit
- Molecular classification
- Receptor, Tyrosine Kinase, Receptor Tyrosine Kinase, Type III receptor tyrosine kinase
01
Overview
The stem cell factor receptor, c-Kit (CD117), is a type III receptor tyrosine kinase activated by stem cell factor (SCF). It plays crucial roles in hematopoiesis, melanogenesis, gametogenesis, and mast cell development. Dysregulation, particularly activating mutations, is implicated in various cancers, including GISTs and leukemia. Therapeutic targeting involves small-molecule tyrosine kinase inhibitors like imatinib, sunitinib, and sorafenib.
- Other names
- CD117proto-oncogene receptor tyrosine kinaseKIT
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
HematopoiesisMelanogenesisGametogenesisMast cell development and functionSignal transductionCell proliferationCell survivalGastrointestinal motilityNervous system development
04
Disease associations
CancerGastrointestinal stromal tumors (GISTs)MastocytosisMelanomaAcute myeloid leukemiaPiebaldism
05
Safety considerations
Resistance to tyrosine kinase inhibitorsOff-target effects of multikinase inhibitorsDevelopment of secondary malignanciesCardiovascular side effects
06
Interacting drugs
Imatinib mesylate
2 more in the full profile.
07
Biomarkers
KIT mutations (e.g., in GISTs)c-Kit expression levels
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