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Target intelligence / Profile preview
Stem Cell Factor Receptor KIT (c-Kit)
- Target
- c-Kit
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
The stem cell factor receptor, also known as c-Kit or CD117, is a type III receptor tyrosine kinase. It is activated by its ligand, stem cell factor (SCF), leading to dimerization and autophosphorylation. Activated c-Kit initiates downstream signaling pathways that regulate cell survival, proliferation, migration, and differentiation. It is expressed on hematopoietic stem cells, mast cells, melanocytes, germ cells, and other cell types. Deregulated c-Kit activity is implicated in various diseases, including gastrointestinal stromal tumors (GISTs), piebaldism, and allergic responses.
- Other names
- CD117proto-oncogene c-kitMast/stem cell growth factor receptorSCFR
02
Mechanism of action
Small-molecule inhibitors that target the tyrosine kinase activity of c-Kit, blocking its signaling pathways.
03
Biological functions
Signal transductionHematopoiesisMelanogenesisGametogenesisCell survivalCell proliferationCell differentiationMast cell developmentGut motility
04
Disease associations
CancerPiebaldismAllergy
05
Safety considerations
Potential for off-target effects due to multi-kinase inhibition by some drugs.Resistance to inhibitors can develop through mutations in the KIT gene.
06
Interacting drugs
Imatinib mesylate
2 more in the full profile.
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