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Sterile Alpha and TIR Motif Containing 1 (SARM1)
- Target
- SARM1
- Molecular classification
- Enzyme, NAD+ nucleosidase, Toll/Interleukin receptor-1 (TIR) family member
01
Overview
Sterile Alpha and TIR Motif Containing 1 (SARM1) is an evolutionarily conserved enzyme that functions as an NAD+ nucleosidase. It plays a critical role in programmed axon death (Wallerian degeneration) by depleting axonal NAD+ upon activation. SARM1 is a therapeutic target for neurodegenerative diseases, and its inhibition has shown promise in preventing axon loss after injury or in disease. While it was initially studied for its role in innate immunity, its neuronal function is now considered more prominent. SARM1 is expressed primarily in neurons and also found in macrophages and T cells.
- Other names
- MyD88-5SAMD2SARMhHsTIR
02
Mechanism of action
Inhibition of SARM1 NAD+ nucleosidase activity to prevent axonal degeneration.
03
Biological functions
Axon degenerationWallerian degenerationNAD+ cleavageRegulation of immune signalingSensor of metabolic stress
04
Disease associations
Neurodegenerative diseaseAmyotrophic Lateral Sclerosis (ALS)
05
Safety considerations
Potential for off-target effects in immune cells.Long-term effects of SARM1 inhibition are not fully understood.
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