Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Sterile alpha motif domain-containing protein 13 (SAMD13)
- Target
- SAMD13
- Molecular classification
- Other, Epigenetic regulator
01
Overview
Sterile alpha motif domain-containing protein 13 is a protein with a SAM domain implicated in chromatin and histone binding, regulating transcription, and epigenetic processes. In cancers such as hepatocellular carcinoma, elevated levels of SAMD13 are correlated with poor prognosis and aggressive tumor features. SAMD13 is associated with immune cell infiltration and cell cycle regulation, and its gene methylation status may serve as a prognostic biomarker. Although not currently a direct therapeutic target, SAMD13's biological roles point toward potential importance in cancer biology and future therapeutic or diagnostic applications.
- Other names
- HSD-42HSD42HSD-41SAM domain-containing protein 13DJLsterile alpha motif domain-containing protein 13SAMD13dnaj-like protein (LOC148418)
02
Biological functions
Negative regulation of transcriptionChromatin bindingHistone bindingRegulation of cell cycle (especially mitotic cell cycle and G1/S transition)Methyl-CpG bindingRibosome biogenesis and spliceosome functionProtein localization to chromosomes, rRNA metabolism, ncRNA processing, ribonucleoprotein complex biogenesisImmune response modulation (associated with immune cell infiltration in tumors)
03
Disease associations
Cancer (implicated in prognosis of hepatocellular carcinoma and correlated with aggressive cancer phenotypes in other tumors)Biomarker for hepatocellular carcinoma (HCC)Other roles in tumor progression, invasion, and metastasis
04
Safety considerations
Potential off-target effects if SAMD13 is inhibited or modulated, given its broad role in transcription and chromatin structureUnknown effects due to lack of existing therapeutics targeting SAMD13
05
Biomarkers
SAMD13 mRNA/protein expression levels (used for prognosis in HCC and potentially other cancers)SAMD13 gene methylation status (CpG methylation sites as prognostic biomarkers in HCC)
Beyond the preview
Go deeper on Sterile alpha motif domain-containing protein 13 (SAMD13).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Sterile alpha motif domain-containing protein 13 (SAMD13).