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Sterile alpha motif domain-containing protein 15 (SAMD15)
- Target
- SAMD15
- Molecular classification
- Other (SAM domain-containing protein; not classified among enzymes, receptors, ion channels, or transporters)
01
Overview
Sterile alpha motif domain-containing protein 15 (SAMD15) is a protein encoded by the SAMD15 gene on chromosome 14[3][5][6]. Its defining feature is the presence of a sterile alpha motif (SAM) domain, a conserved protein interaction module that mediates self-association and interaction with other SAM- or non-SAM domain-containing proteins[2][7]. SAM domains can also, in some cases, bind RNA, though this has not specifically been shown for SAMD15[2]. SAMD15 is predicted to participate in cellular signal transduction and may enable serine/threonine kinase activation[6]. The molecular and physiological functions of SAMD15 in humans remain incompletely defined, and there are no established disease associations or therapeutic applications. It is classified as a protein-coding gene and is not considered a canonical receptor, enzyme, transporter, or transcription factor[5][7].
- Other names
- C14orf174FAM15AFLJ35963family with sequence similarity 15 member ASAM domain-containing protein 15
02
Biological functions
Signal transduction (predicted involvement)Protein-protein interactions via SAM domainMay enable protein serine/threonine kinase activator activity (predicted)
03
Disease associations
Other (No well-established direct connection to specific diseases; no current evidence linking SAMD15 directly to cancer, inflammation, infection, neurodegeneration, or cardiovascular disease)
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