Sterile alpha motif domain-containing protein 7 (SAMD7)

Sterile alpha motif domain-containing protein 7 (SAMD7) is a nuclear protein essential for the epigenetic regulation of gene expression in retinal photoreceptor cells. It acts as a transcriptional corepressor by interacting with transcription factors such as Cone-Rod Homeobox (CRX) and rod-specific Nr2e3, recruiting the Polycomb repressive complex 1 (PRC1) to mediate gene silencing through chromatin modification. SAMD7 specifically silences nonrod gene expression in rod photoreceptor cells by promoting H3K27me3 deposition and chromatin compaction, thus defining rod cell identity. Mutations in SAMD7 cause autosomal-recessive macular dystrophy, highlighting its crucial role in human retinal function[1][2][3][5][6]. SAMD7 is primarily expressed in the retina, localized to the nuclei of rods and cones, and the inner nuclear layer of the retina[2][3][5]. There is currently no evidence that SAMD7 is a direct drug target or that drugs interact with this protein.

Other names

SAMD7Sterile alpha motif domain containing 7SAM domain-containing protein 7DKFZp686E1583MDCD

No drugs act on SAMD7, so mechanisms of drug action targeting it are unavailable.