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Target intelligence / Profile preview
Steroid 17-alpha-hydroxylase (CYP17A1)
- Target
- CYP17A1
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Steroid 17-alpha-hydroxylase (CYP17A1) is a key enzyme in steroid hormone biosynthesis, belonging to the cytochrome P450 superfamily. It exhibits both 17α-hydroxylase and 17,20-lyase activities, essential for the production of glucocorticoids, androgens, and estrogens. Mutations in CYP17A1 can lead to congenital adrenal hyperplasia and other disorders affecting sexual development and electrolyte balance. It is considered a therapeutic target to modulate steroid hormone synthesis.
- Other names
- Cytochrome P450c17P450 17A117alpha-hydroxylase17,20-lyase
02
Mechanism of action
Inhibition of CYP17A1, blocking the synthesis of cortisol and sex steroids.
03
Biological functions
Steroid hormone biosynthesisGlucocorticoid synthesisAndrogen synthesisEstrogen synthesisRegulation of sexual developmentRegulation of reproductionBlood pressure regulationGlucose metabolism
04
Disease associations
Congenital Adrenal HyperplasiaHypertensionPseudohermaphroditismElectrolyte imbalanceAdrenal hyperplasiaPubertal failure
05
Safety considerations
HypertensionHypokalemiaAbnormal sexual developmentAdverse effects related to altered steroid hormone levels
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