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Target intelligence / Profile preview
Steroid 17-alpha-monooxygenase (CYP17)
- Target
- CYP17
- Molecular classification
- Enzyme, Cytochrome P450 superfamily, Monooxygenase
01
Overview
Steroid 17-alpha-monooxygenase, encoded by the CYP17A1 gene, is a crucial enzyme in steroid hormone biosynthesis. It catalyzes both 17α-hydroxylation and 17,20-lyase reactions, converting pregnenolone and progesterone into precursors for glucocorticoids and sex hormones. CYP17A1 is primarily expressed in the adrenal cortex and gonadal tissues. Its activity is regulated by cofactors such as cytochrome P450 oxidoreductase and cytochrome b5, as well as phosphorylation. Mutations in CYP17A1 can lead to various disorders, including congenital adrenal hyperplasia and disorders of sexual development. Targeted inhibition of CYP17A1 is used therapeutically in prostate cancer.
- Other names
- CYP17A1Cytochrome P450 17α-hydroxylase/17,20-lyase
02
Mechanism of action
Inhibition of steroid 17-alpha-monooxygenase activity
03
Biological functions
SteroidogenesisGlucocorticoid biosynthesisSex hormone biosynthesisHydroxylationCarbon-carbon bond cleavage
04
Disease associations
Congenital adrenal hyperplasia type VDisorders of sexual developmentAdrenal hyperplasia with hypertensionProstate cancer
05
Safety considerations
Potential for mineralocorticoid excess when glucocorticoid/sex hormone pathways are blockedSide effects related to androgen deprivation
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