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Target intelligence / Profile preview
Steroid 3-oxo-5α-steroid 4-dehydrogenase 2 (None)
- Target
- None
- Molecular classification
- Enzyme, Steroid reductase
01
Overview
5-alpha-reductase type II (SRD5A2) is a microsomal enzyme that catalyzes the conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen. This reaction is essential for normal male sexual differentiation and development. Mutations in SRD5A2 can cause 5-alpha reductase deficiency, leading to underdeveloped or ambiguous external genitalia in genetic males. It is also implicated in prostate cancer and is the target of drugs like finasteride used to treat benign prostatic hyperplasia and androgenetic alopecia.
- Other names
- 5-alpha reductase type IISRD5A2Steroid 5-alpha-reductase, type II
02
Mechanism of action
Inhibition of 5-alpha reductase type II, preventing the conversion of testosterone to dihydrotestosterone (DHT)
03
Biological functions
Steroid metabolismAndrogen biosynthesisDihydrotestosterone (DHT) production
04
Disease associations
Male pseudohermaphroditism/46XY DSDProstate cancerBenign Prostatic HyperplasiaAndrogenetic Alopecia
05
Safety considerations
Sexual dysfunctionTeratogenicity (inhibition of fetal male development)Potential impact on prostate cancer risk (controversial)
06
Interacting drugs
Finasteride
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