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Target intelligence / Profile preview
Steroid 5α-reductase type 2 (5α-RD2)
- Target
- 5α-RD2
- Molecular classification
- Enzyme
01
Overview
5α-reductase type 2 (5α-RD2 or SRD5A2) is a membrane-bound enzyme that catalyzes the irreversible conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen. This reaction is essential for normal male sexual differentiation, particularly the development of external genitalia before birth. Mutations in SRD5A2 cause 5-alpha reductase deficiency, resulting in underdeveloped male genitalia at birth. Its expression changes are implicated during prostate cancer progression. Drugs like finasteride selectively inhibit type 2 isoenzyme activity.
- Other names
- SRD5A2
02
Mechanism of action
Inhibition of 5α-reductase activity, preventing the conversion of testosterone to dihydrotestosterone (DHT).
03
Biological functions
Steroid metabolismAndrogen productionMale sexual differentiation
04
Disease associations
Disorders of sex development (DSDs)Prostate cancer
05
Safety considerations
Potential impact on male sexual development in utero if exposed during pregnancy.Sexual dysfunction
06
Interacting drugs
Finasteride
1 more in the full profile.
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