Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Steroid 5α-reductase type I
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
5α-reductase type 1 is an isoenzyme of the steroid 5α-reductase family, which catalyzes the conversion of testosterone to dihydrotestosterone (DHT). It is encoded by the SRD5A1 gene and is highly expressed in liver and skin. DHT produced by this enzyme is essential for male sexual differentiation and development. Overexpression is observed during prostate cancer progression. It is targeted by 5α-reductase inhibitors like finasteride, used for benign prostatic hyperplasia and androgenic alopecia.
- Other names
- Steroid Δ4–3-ketosteroid–Δ4–reductaseTestosterone Δ4–reductaseOxosteroid(acceptor)Δ4–oxidoreductaseTestosterone reductase
02
Mechanism of action
5α-reductase inhibitor
03
Biological functions
Steroid metabolismAndrogen biosynthesisGlucocorticoid metabolism
04
Disease associations
Prostate cancerBenign prostatic hyperplasiaAndrogenic alopeciaMetabolic syndromeInsulin resistanceHepatic steatosis
05
Safety considerations
Increased testosterone/estradiol levels due to reduced conversion rate when inhibited.
06
Interacting drugs
Finasteride
Beyond the preview
Go deeper on Steroid 5α-reductase type I.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Steroid 5α-reductase type I.