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Steroid 5α-Reductase Type II (5α-Reductase Type II)
- Target
- 5α-Reductase Type II
- Molecular classification
- Enzyme, Steroid reductase, Oxidoreductase
01
Overview
Steroid 5α-reductase type II is an enzyme that catalyzes the conversion of testosterone to dihydrotestosterone (DHT). DHT is a potent androgen that plays a crucial role in male sexual differentiation and development. Inhibition of this enzyme is a therapeutic strategy for conditions such as benign prostatic hyperplasia and prostate cancer.
- Other names
- SRD5A25-alpha reductase type 2Testosterone 5 alpha-reductase 2
02
Mechanism of action
Inhibition of steroid 5α-reductase type II, preventing the conversion of testosterone to dihydrotestosterone (DHT)
03
Biological functions
Steroid metabolismConversion of testosterone to dihydrotestosterone (DHT)Androgen signaling
04
Disease associations
Benign Prostatic Hyperplasia (BPH)Prostate cancerMale pseudohermaphroditismAmbiguous genitalia
05
Safety considerations
Sexual dysfunctionProstate cancer risk (long-term use)Teratogenicity (contraindicated in pregnant women)
06
Interacting drugs
Finasteride
1 more in the full profile.
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