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Target intelligence / Profile preview
Steroid 5-alpha-reductase type 1 (5αR1)
- Target
- 5αR1
- Molecular classification
- Enzyme, Steroid reductase
01
Overview
Steroid 5-alpha-reductase type 1 (5αR1) is an enzyme encoded by the SRD5A1 gene that catalyzes the conversion of testosterone to dihydrotestosterone (DHT), as well as similar reductions for other steroid hormones. It is predominantly expressed in the liver and skin. It is a therapeutic target for benign prostatic hyperplasia and is implicated in various metabolic diseases and cancer.
- Other names
- 5-alpha-reductase 1SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase 1
02
Mechanism of action
Inhibition of 5-alpha-reductase activity, reducing DHT production.
03
Biological functions
Steroid metabolismAndrogen biosynthesisNeurosteroid synthesis
04
Disease associations
Endometrioid endometrial adenocarcinomaInsulin resistanceHepatic steatosisHepatic fibrosis
05
Safety considerations
Potential metabolic side effects (insulin resistance, hepatic steatosis)Individual variability in response to inhibitors
06
Interacting drugs
Dutasteride
1 more in the full profile.
07
Biomarkers
Intratumoral DHT concentrationsSRD5A1 expression levels
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