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Steroid 5-alpha-reductase type I (None)

Target: None
Molecular classification: Enzyme, Oxidoreductase

Overview

Steroid 5-alpha-reductase type I (SRD5A1) is an enzyme that catalyzes the irreversible conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen. It plays a key role in androgen metabolism, influencing cell proliferation, migration, angiogenesis, and tumorigenesis. SRD5A1 is primarily expressed in non-reproductive tissues like liver and skin.

Mechanism of action

Inhibition of steroid 5-alpha-reductase, preventing the conversion of testosterone to dihydrotestosterone (DHT).

Biological functions

Androgen metabolismSteroid metabolismCell proliferationCell migrationAngiogenesisRegulation of gene expression

Disease associations

Prostate cancerBreast cancerColorectal cancerNon-small cell lung cancerLiver cancer

Interacting drugs

Dutasteride

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