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Target intelligence / Profile preview
Steroid 5-alpha-reductase type II (5α-reductase type II)
- Target
- 5α-reductase type II
- Molecular classification
- Enzyme, Oxidoreductase, Steroid enzyme
01
Overview
Steroid 5-alpha-reductase type II is an enzyme that converts testosterone to dihydrotestosterone (DHT), a more potent androgen. It is encoded by the SRD5A2 gene and plays a crucial role in male sexual development. Inhibitors of this enzyme, such as finasteride and dutasteride, are used to treat benign prostatic hyperplasia and androgenetic alopecia.
- Other names
- 3-oxo-5 alpha-steroid 4-dehydrogenase 2Type II 5-alpha reductaseS5A2_HUMAN
02
Mechanism of action
Inhibition of steroid 5-alpha-reductase type II, reducing DHT production.
03
Biological functions
Steroid metabolismAndrogen biosynthesisTestosterone conversion to dihydrotestosterone (DHT)Male sexual development
04
Disease associations
Steroid 5-alpha reductase deficiencyAmbiguous genitaliaPolycystic ovary syndrome (PCOS)Benign prostatic hyperplasia (BPH)Androgenetic alopecia
05
Safety considerations
Sexual dysfunctionGynecomastiaTeratogenic effects (inhibition of male fetal development)
06
Interacting drugs
Finasteride
1 more in the full profile.
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