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Target intelligence / Profile preview
Steroid 5-alpha-reductase type III (SRD5A3)
- Target
- SRD5A3
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Steroid 5-alpha-reductase type III (SRD5A3) is an enzyme that catalyzes the conversion of testosterone to dihydrotestosterone (DHT). It is implicated in prostate cancer and other cancers where it may contribute to androgen synthesis and resistance to conventional therapies. SRD5A3 also plays a role in dolichol synthesis which is required for N-linked protein glycosylation.
- Other names
- Steroid 5 alpha-reductase type III
02
Mechanism of action
Inhibits the conversion of testosterone to dihydrotestosterone (DHT).
03
Biological functions
Steroid metabolismAndrogen synthesisDolichol synthesisN-linked protein glycosylation
04
Disease associations
Prostate cancerCastration-resistant prostate cancer (CRPC)Hepatocellular carcinoma (HCC)Endometrial cancerBenign Prostatic Hyperplasia
05
Safety considerations
Incomplete inhibition of SRD5A3 by current inhibitors at physiological concentrationsPotential for alternative androgen biosynthesis pathways to bypass inhibition
06
Interacting drugs
Dutasteride
07
Biomarkers
SRD5A3 mRNA expression in tumor tissue
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