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Target intelligence / Profile preview
Steroid hormone receptor ERR1 (ERRα)
- Target
- ERRα
- Molecular classification
- Nuclear hormone receptor, Transcription factor
01
Overview
Steroid hormone receptor ERR1 (ERRα) is a member of the nuclear receptor family of transcription factors. It regulates genes involved in mitochondrial biogenesis, energy metabolism, fatty acid oxidation, and steroidogenesis. It does not bind estrogens but can be modulated by synthetic compounds. ERRα plays a role in cancer biology, particularly in promoting migration, invasion, and angiogenesis of breast cancer stem cell-like cells.
- Other names
- Estrogen-related receptor alphaERR1ESRRA
02
Mechanism of action
Binds to estrogen-related response elements (ERRE) and modulates transcription of target genes; interacts with coactivators such as PGC-1α to enhance transcriptional activity. Synthetic agonists can modulate conformation.
03
Biological functions
Transcriptional regulationRegulation of energy metabolismMitochondrial biogenesisFatty acid oxidationSteroidogenesis
04
Disease associations
Metabolic disordersCancerBreast cancer
05
Safety considerations
Dysregulation implicated in cancer progression.
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