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Steroid hormone receptor ERR2 (ERR2)
- Target
- ERR2
- Molecular classification
- Nuclear receptor, Steroid hormone receptor, Transcription factor
01
Overview
Steroid hormone receptor ERR2 (ESRRB/ERRβ) is a member of the nuclear receptor superfamily of transcription factors. It plays a critical role in stem cell maintenance and developmental processes, including inner ear development and photoreceptor survival. ERR2 functions by binding to specific DNA sequences (ERRE) and regulating the expression of target genes, acting as both an activator and repressor of transcription. While structurally similar to estrogen receptors, it does not bind estrogens and is considered an orphan receptor with poorly defined endogenous ligands. Its function is especially prominent during early developmental stages.
- Other names
- Estrogen-related receptor betaERRβESRRBNR3B2
02
Mechanism of action
Transcription activation/repression via direct DNA binding to the ERRE motif (5'-TCAAGGTCA-3')
03
Biological functions
Transcription regulationStem cell maintenanceRegulation of gene expressionRegulation of cell differentiationRegulation of cell survival
04
Disease associations
Developmental disordersCancer (potentially, through its role in proliferation and metabolism)Hearing loss (inner ear development)Retinal degeneration
05
Safety considerations
Potential for off-target effects due to structural similarity to other nuclear receptorsModulation of stem cell pluripotency may have unintended developmental consequencesActivation or inhibition of ERR2 in cancer cells could have opposing effects depending on the tumor type
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