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Target intelligence / Profile preview
Steroid Sulfatase (STS)
- Target
- STS
- Molecular classification
- Enzyme, Sulfatase, Hydrolase
01
Overview
Steroid sulfatase (STS) is an enzyme (EC 3.1.6.2) that catalyzes the hydrolysis of steroid sulfates into their unconjugated forms, regulating the formation and bioavailability of biologically active steroids. It is a therapeutic target in hormone-dependent cancers and its deficiency leads to X-linked ichthyosis. Inhibitors of STS, such as Irosustat, are being developed to reduce local estrogen synthesis in tumors.
- Other names
- Steryl-sulfataseArylsulfatase CARSCARSC2ARSC1ASCESSSDDXLI
02
Mechanism of action
Inhibition of steroid sulfatase, reducing local estrogen synthesis.
03
Biological functions
Steroid metabolismHormone regulationHydrolysis of steroid sulfatesRegulation of steroid bioavailability
04
Disease associations
X-linked ichthyosisBreast cancerProstate cancerCognitive dysfunction
05
Safety considerations
Potential endocrine disruptionOff-target effects
06
Interacting drugs
Irosustat (667 COUMATE)
07
Biomarkers
STS expression levels in tumors
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