Steroid transmembrane transporter SLC22A24 (SLC22A24)

SLC22A24 (Steroid transmembrane transporter SLC22A24) is a member of the solute carrier (SLC) family 22, specifically mediating the transport of organic ions, including conjugated steroids and bile acids, across cell membranes as a renal transmembrane organic anion/dicarboxylate exchanger. It is mainly expressed in the kidney, where it participates in the reabsorption of steroid conjugates such as estradiol-17beta-glucuronide, androstanediol glucuronide, and estrone 3-sulfate, as well as bile acids like taurocholate and glycocholate. SLC22A24 plays a crucial role in modulating steroid hormone homeostasis, with genetic variants linked to altered metabolite levels and disease predisposition, including cardiovascular disease and acne. As an orphan transporter, it represents a promising pharmacological target for conditions related to steroid imbalance. No direct approved therapeutics target SLC22A24 at present, but its function and associations suggest potential utility in future drug development or biomarker discovery.

Other names

SLC22A24Solute carrier family 22 member 24NET46MGC34821Steroid transmembrane transporter SLC22A24C9JC66Q8N4F4

For investigational drugs or modulators (none currently approved): Inhibition or enhancement of transporter function could modify cellular uptake of steroid conjugates or bile acids. Mechanism would typically involve binding and allosteric regulation or competitive inhibition of transporter activity.