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Target intelligence / Profile preview
Sterol 24-C-methyltransferase (SMT)
- Target
- SMT
- Molecular classification
- Enzyme, Methyltransferase, Transferase
01
Overview
Sterol 24-C-methyltransferase (SMT) is an enzyme that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to the C-24 position of sterols, a key step in the biosynthesis of ergosterol and other sterols in fungi, protozoa, plants, and some algae. It is not present in mammals, making it a promising drug target for antifungal and antiparasitic therapies. Inhibition of SMT disrupts sterol homeostasis, leading to impaired fungal/protozoal growth and viability.
- Other names
- Delta24-sterol methyltransferaseZymosterol-24-methyltransferaseSMT1Phytosterol methyltransferaseDelta(24)-methyltransferaseS-Adenosylmethionine:steroldelta(24)-methyltransferase
02
Mechanism of action
Inhibition of sterol biosynthesis
03
Biological functions
Sterol biosynthesisErgosterol biosynthesisMembrane integrity maintenance
04
Disease associations
Fungal infectionsParasitic diseasesAzole resistance
05
Safety considerations
Potential for off-target effects if inhibitors are not highly selective.
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