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Target intelligence / Profile preview
Sterol 27-hydroxylase (CYP27A1)
- Target
- CYP27A1
- Molecular classification
- Enzyme, Cytochrome P450 family
01
Overview
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P450 enzyme that catalyzes the hydroxylation of cholesterol at the C-27 position, a key step in bile acid biosynthesis. Mutations in CYP27A1 cause cerebrotendinous xanthomatosis (CTX), a lipid storage disorder with severe neurological consequences. The enzyme plays a vital role in cholesterol homeostasis, reverse cholesterol transport, and regulation of cholesterol synthesis. Its expression is highest in the liver but also significant in peripheral tissues, macrophages, and glial cells.
- Other names
- Cytochrome P450 family 27 subfamily A member 1CP27CTXCYP27[2]
02
Mechanism of action
Chenodeoxycholic acid treatment restores feedback inhibition on alternative metabolic pathways responsible for harmful metabolite buildup.
03
Biological functions
Cholesterol homeostasisBile acid biosynthesisReverse cholesterol transportRegulation of cholesterol synthesis
04
Disease associations
Cerebrotendinous xanthomatosisAtherosclerosisNeurological impairmentLipid storage disorder
05
Safety considerations
Potential for drug interactions due to cytochrome P450 activityNeed for early diagnosis and treatment to prevent severe neurological consequences in CTX
06
Interacting drugs
Chenodeoxycholic acid
07
Biomarkers
Cholestanol levels (elevated in CTX)27-hydroxycholesterol levels
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