Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Sterol Isomerase (Emopamil-Binding Protein) (None)
- Target
- None
- Molecular classification
- Enzyme, Isomerase, Membrane protein
01
Overview
Emopamil-binding protein (EBP), also known as sterol Δ8-Δ7 isomerase, is an integral membrane protein located primarily in the endoplasmic reticulum of mammalian cells. EBP catalyzes a key step in cholesterol biosynthesis: the isomerization of the double bond from C8–C9 to C7–C8 in sterol intermediates, specifically converting 8,9-cholestenol into lathosterol. Mutations in *EBP* cause Conradi-Hünermann syndrome. Inhibition of EBP promotes oligodendrocyte formation and remyelination, and may also induce tumor cell death.
- Other names
- EBPCholestenol delta-isomeraseDelta(8)-Delta(7) sterol isomeraseD8-D7 sterol isomeraseEmopamil-binding protein
02
Mechanism of action
Inhibition of sterol Δ8-Δ7 isomerase activity, leading to disruption of cholesterol biosynthesis.
03
Biological functions
Cholesterol biosynthesisSterol metabolismDrug binding
04
Disease associations
Conradi-Hünermann syndromeMultiple SclerosisCancer
05
Safety considerations
Inhibition of cholesterol biosynthesis can have developmental consequences.Off-target effects due to structural similarity of inhibitors with other proteins.
06
Interacting drugs
Emopamil
8 more in the full profile.
Beyond the preview
Go deeper on Sterol Isomerase (Emopamil-Binding Protein) (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Sterol Isomerase (Emopamil-Binding Protein) (None).