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Target intelligence / Profile preview
Sterol Isomerase (Emopamil-Binding Protein)
- Molecular classification
- Enzyme, Isomerase, Membrane protein
01
Overview
Emopamil-binding protein (EBP), also known as sterol Δ8-Δ7 isomerase, is an integral membrane protein located primarily in the endoplasmic reticulum of mammalian cells. EBP catalyzes a key step in cholesterol biosynthesis: the isomerization of the double bond from C8–C9 to C7–C8 in sterol intermediates, specifically converting 8,9-cholestenol into lathosterol. Mutations in *EBP* cause Conradi-Hünermann syndrome. Inhibition of EBP promotes oligodendrocyte formation and remyelination, and may also induce tumor cell death.
- Other names
- EBPCholestenol delta-isomeraseDelta(8)-Delta(7) sterol isomeraseD8-D7 sterol isomeraseEmopamil-binding protein
02
Mechanism of action
Inhibition of sterol Δ8-Δ7 isomerase activity, leading to disruption of cholesterol biosynthesis.
03
Biological functions
Cholesterol biosynthesisSterol metabolismDrug binding
04
Disease associations
Conradi-Hünermann syndromeMultiple SclerosisCancer
05
Safety considerations
Inhibition of cholesterol biosynthesis can have developmental consequences.Off-target effects due to structural similarity of inhibitors with other proteins.
06
Interacting drugs
Emopamil
8 more in the full profile.
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