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Target intelligence / Profile preview
Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)
- Target
- ACAT2
- Molecular classification
- Enzyme, Acyltransferase, Membrane protein
01
Overview
Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is a membrane-bound enzyme primarily expressed in hepatocytes and enterocytes. It catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty acyl-CoA, which are then incorporated into lipoproteins or stored in lipid droplets. ACAT2 plays a crucial role in cholesterol homeostasis and dietary fat absorption. It is a therapeutic target for hyperlipidemia and atherosclerosis.
- Other names
- SOAT2Sterol O-acyltransferase 2
02
Mechanism of action
Inhibition of ACAT2 reduces cholesteryl ester formation and apoB-lipoprotein secretion.
03
Biological functions
Cholesterol esterificationLipid storageLipoprotein assemblyCholesterol homeostasisDietary fat absorption
04
Disease associations
HypercholesterolemiaAtherosclerosisCardiovascular diseaseAlzheimer's disease
05
Interacting drugs
Pyripyropene A
1 more in the full profile.
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