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Target intelligence / Profile preview
Sterol Regulatory Element-Binding Protein (SREBP)
- Target
- SREBP
- Molecular classification
- Transcription factor, bHLH-LZ transcription factor
01
Overview
Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that regulate lipid homeostasis. They control the synthesis and uptake of cholesterol, fatty acids, triglycerides, and phospholipids. Activation involves proteolytic cleavage and translocation to the nucleus to upregulate target genes. Dysregulation is implicated in metabolic diseases and cancer, making them potential therapeutic targets.
- Other names
- SREBF1SREBF2
02
Mechanism of action
Inhibition of SREBP activation or downstream target gene expression
03
Biological functions
Regulation of lipid metabolismCholesterol biosynthesisFatty acid synthesisTriglyceride synthesisPhospholipid synthesisRegulation of gene expression
04
Disease associations
ObesityDiabetes mellitus type IINon-alcoholic fatty liver diseaseCancer
05
Safety considerations
Potential for off-target effects due to broad role in lipid metabolismDisruption of lipid homeostasis
06
Interacting drugs
Natural compounds (targeting SREBP)
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