Sterol regulatory element-binding protein 1-c (SREBP-1c)

Sterol regulatory element-binding protein 1-c (SREBP-1c) is a transcription factor primarily regulating genes involved in lipid (especially fatty acid) and cholesterol biosynthesis. Encoded by the SREBF1 gene, SREBP-1c arises from alternative promoter usage distinct from the related isoform SREBP-1a. SREBP-1c is predominantly expressed in liver, fat, and muscle tissues, where it controls rates of *de novo* lipogenesis in response to metabolic cues such as insulin and dietary carbohydrate. SREBP-1c function is modulated by proteolytic cleavage, post-translational modification, and transcriptional regulation by hormones and sterol metabolites. Its dysregulation plays a central role in conditions like non-alcoholic fatty liver disease, insulin resistance, and metabolic syndrome [1][4][5][6][7].

Other names

Sterol regulatory element-binding transcription factor 1-cSREBP-1cADD-1

Inhibition of SREBP-1c expression (e.g. by statins/compactin) to reduce lipogenesis; Modulation of SREBP-1c activation (e.g. LXR/PPARα agonists upregulate SREBP-1c transcription); Downregulation by glucagon; Upregulation by insulin (used experimentally or via metabolic intervention) [1][3][5][6]