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Target intelligence / Profile preview
Sterol Regulatory Element-Binding Protein 2 (SREBP2)
- Target
- SREBP2
- Molecular classification
- Transcription factor
01
Overview
Sterol Regulatory Element-Binding Protein 2 (SREBP2) is a transcription factor that primarily regulates genes involved in cholesterol biosynthesis and uptake. It is anchored to the endoplasmic reticulum when intracellular cholesterol levels are high and is released and activated when cholesterol levels decrease. Upon activation, SREBP2 is cleaved by site-1 protease (S1P) and site-2 protease (S2P), releasing the NH2-terminal fragment (nSREBP2), which then translocates to the nucleus to activate target genes. Variants of the SREBF2 gene have been associated with an increased risk of knee osteoarthritis, and SREBP2 is being explored as a potential target for therapies related to lipid metabolism disorders, such as non-alcoholic steatohepatitis (NASH).
- Other names
- SREBF2
02
Mechanism of action
Modulation of cholesterol and fatty acid metabolism
03
Biological functions
Cholesterol biosynthesis and uptake regulationRegulation of lipid metabolismRegulation of gene expression
04
Disease associations
Knee osteoarthritisNon-alcoholic steatohepatitis (NASH)Lipid metabolism disorders
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