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Stimulator of Interferon Genes 1 (STING)
- Target
- STING
- Molecular classification
- Adaptor protein, Cytosolic DNA sensor
01
Overview
STING (Stimulator of Interferon Genes 1) is a critical adaptor protein in the innate immune system. It functions as a cytosolic DNA sensor and adaptor for DNA-sensing pathways, activating type I interferon responses. Upon detection of cytosolic DNA, cGAS synthesizes cGAMP, which binds to and activates STING, triggering downstream signaling cascades leading to the production of type I interferons and other cytokines. Mutations in STING can cause autoinflammatory diseases like SAVI.
- Other names
- TMEM173MPYSMITAERISendoplasmic reticulum IFN stimulator
02
Mechanism of action
Cyclic GMP-AMP (cGAMP) binding, TBK1 activation, IRF3 activation, Type I interferon induction
03
Biological functions
Innate immunityDNA sensingType I interferon productionAutophagy regulationApoptosis regulationGene transcription modulationDNA damage response
04
Disease associations
Autoinflammatory diseasesSTING-associated vasculopathy with onset in infancy (SAVI)Viral infections
05
Safety considerations
Excessive beta-interferon productionChronic overactivation of the immune systemPotential for autoinflammatory diseases
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