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Target intelligence / Profile preview
Stimulator of interferon genes protein (STING)
- Target
- STING
- Molecular classification
- Adaptor protein, Transmembrane protein
01
Overview
STING is a critical adaptor protein in the innate immune system that acts as a cytosolic DNA sensor and triggers type I interferon production. Upon detection of cytosolic DNA or binding of cyclic dinucleotides (CDNs), STING undergoes conformational changes, translocates to perinuclear compartments, recruits TBK1 kinase, and activates IRF3, leading to the expression of interferon-stimulated genes. STING plays a role in antiviral defense, cancer immunity, and inflammatory responses, making it a therapeutic target for infectious diseases, cancer immunotherapy, and inflammatory disorders. Pharmacological modulation of STING, using both agonists and inhibitors, is under investigation for clinical use.
- Other names
- TMEM173MPYSMITAERIS
02
Mechanism of action
Agonists: Activation of STING leading to interferon production and immune stimulation. Inhibitors: Blockade of STING activation, dampening interferon production and inflammatory response.
03
Biological functions
Innate immunityType I interferon signalingCytosolic DNA sensingAntiviral defenseInflammation
04
Disease associations
Infectious diseasesCancerInflammatory disordersAutoimmune diseases (potential)
05
Safety considerations
Excessive inflammationAutoimmunity
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