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Target intelligence / Profile preview
Stimulatory Guanine Nucleotide-Binding Protein Alpha Subunit (Gsα)
- Target
- Gsα
- Molecular classification
- Heterotrimeric G protein, G protein alpha subunit, GTPase
01
Overview
The Gs alpha subunit (Gαs) is a key component of the heterotrimeric G protein complex that couples cell surface receptors to adenylyl cyclase, stimulating cAMP production. Encoded by the *GNAS* gene, it plays a central role in cellular signal transduction. Mutations can lead to constitutive activation and disease.
- Other names
- G alpha s subunitGs alpha subunitGαsGNAS
02
Mechanism of action
Gsα stimulates adenylyl cyclase, leading to increased cAMP production and activation of downstream targets like Protein Kinase A (PKA).
03
Biological functions
Signal transductionAdenylyl cyclase activationcAMP productionGPCR signaling
04
Disease associations
Endocrine disordersTumors
05
Safety considerations
Constitutive activation due to mutations can lead to unregulated cAMP signaling and disease.
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