Stomatin (STOM)

Stomatin is a highly conserved, 31 kDa monotopic integral membrane protein, primarily found in red blood cells but expressed widely across tissues[1][2][6]. It is a member of the SPFH (Stomatin/Prohibitin/Flotillin/HflK/C) domain family and associates with cholesterol-rich domains (lipid rafts) in the plasma membrane, where it acts as a scaffolding protein regulating the activity of numerous ion channels and transporters, including anion exchanger 1 (AE1) and glucose transporter (GLUT1)[5][7]. Stomatin plays a structural role in organizing membrane architecture, modulating ion transport, and influencing processes such as cell division and membrane fusion[3][5]. Loss of stomatin or its mislocalization is linked to hereditary stomatocytosis, a form of hemolytic anemia characterized by sodium and potassium leakage from red blood cells[1][2][6]. There is currently no direct therapeutic targeting of stomatin, but its deficiency or dysfunction serves as a molecular marker in selected blood and bone disorders.

Other names

StomatinBND7EPB72Erythrocyte band 7 integral membrane proteinErythrocyte membrane protein band 7.2Protein 7.2bEPB7erythrocyte surface protein band 7.2