Stonin-2 (STON2)

Stonin-2 (STON2) is an adaptor protein that plays a critical role in clathrin-mediated endocytosis and synaptic vesicle recycling, especially in neural tissue[1][2][3][4][5]. It interacts with endocytic machinery components, such as Eps15, Eps15R, intersectin 1, and synaptotagmins I and II, via highly conserved motifs, and helps recruit these proteins to clathrin-coated vesicles[2][3][4]. Through its mu-homology domain, stonin-2 can bind synaptotagmin I, targeting it to axonal vesicle clusters and facilitating vesicle uncoating and cargo selection during endocytosis[2]. Stonin-2 is widely expressed, enriched in brain, and its dysfunction is implicated in altered neurotransmission and may be associated with certain neurological and cancer phenotypes[5][9]. There are currently no drugs or clinical biomarkers directly targeting or utilizing stonin-2, and it is not classified as a canonical therapeutic target (e.g., it is not a receptor, enzyme, or transporter), but rather as a key endocytic scaffold/adaptor protein[5].

Other names

Stonin-2STN2STNBSTNB2Stoned Bstoned B homolog 2 (Drosophila)Stonin 2stoned B homolog 2