Target intelligence / Profile preview

Store-Operated Calcium Entry Pathway (SOCE)

Target: SOCE
Molecular classification: Ion channel pathway, Signaling pathway

Overview

Store-operated calcium entry represents a central mechanism coupling intracellular store status with external ion fluxes through specialized sensor-channel complexes. Its precise regulation ensures proper cellular function across diverse tissues while its dysfunction underlies several human diseases.

Other names: CRAC channel pathwaySOCC

Mechanism of action

Modulation of calcium influx via STIM/Orai/TRPC channels

Biological functions

Calcium homeostasisSignal transductionGene expression regulationSecretionImmune responseCell proliferation

Disease associations

ImmunodeficiencyCancerInflammationOther

Safety considerations

Potential for immune dysfunctionOff-target effects on calcium signaling

Beyond the preview

Go deeper on Store-Operated Calcium Entry Pathway (SOCE).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Store-Operated Calcium Entry Pathway (SOCE).

Explore the full profile